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For US Healthcare Professionals
Chantal, Martha, and Hannah, MS patients, using OCREVUS

EMPOWER YOURSELF TO TAKE ON YOUR MS

GET THE KNOWLEDGE YOU NEED TO HAVE HELPFUL, PRODUCTIVE CONVERSATIONS WITH YOUR DOCTORS AND FAMILY.

Some evidence suggests Hispanic people with MS begin to show symptoms at a younger age compared to other populations. The good news is that updated guidelines can help with earlier diagnosis, and there’s more research on MS now than ever before. Because the more you know about MS, the better you’ll be able to help people understand how you feel.

If you start to experience symptoms like those below, find a doctor you can trust and talk to them about beginning treatment. Once you begin, continuing to stay on an effective treatment may help slow progression.

Remember, your doctor is there to help. Throughout your treatment it’s okay to speak up and ask any and all questions you may have as you build a partnership for your care. If you don’t feel like you’re connecting with your doctor, you can also continue to seek additional opinions. Help get the conversation started by personalizing our Doctor Discussion Guide.

Personalize My Guide: English
Personalize My Guide: Spanish

WHAT ARE THE SYMPTOMS OF MS?

One symptom Hispanic people living with MS are more likely to experience is optic neuritis, which can include pain with eye movement and temporary vision loss in one eye. If you are experiencing vision problems or any other of these symptoms, talk to a doctor soon.

Tremor or loss of coordination

Fatigue and tremors or loss of coordination

Visual function - problems with sight

Vision problems, involuntary eye movements, and optic nerve function

Problems with speech, swallowing, or involuntary eye movements

Problems with speech and swallowing

Numbness or loss of sensations

Numbness or loss of sensations

Cerebral functions - problems with thinking and memory

Cognitive function, such as difficulty with concentration, vocabulary, and memory

Bowel and bladder function

Bowel and bladder function

Muscle weakness or difficulty moving limbs

Walking and mobility issues

Muscle weakness or difficulty moving limbs

Muscle weakness or difficulty moving limbs

DEDICATED TO HEALTH EQUITY FOR EVERYONE.

At Genentech, we believe everyone deserves support during their MS journey and we are committed to the pursuit of health equity in MS and beyond. Some of the initiatives we are taking include:

  • CHIMES, the first-of-its-kind study in Black and Hispanic people living with MS
  • Raising awareness of MS within the Hispanic community and offering support in both Spanish and English
  • Providing resources to help people talk to their doctor and advocate for themselves

At the core of our mission is improving health outcomes for all patients. Learn more about our commitment to advancing inclusive research to increase representation across all races, ethnicities and ancestries.

Our Commitment to Inclusive Research

THERE IS A COMMUNITY READY TO SUPPORT YOU.

MS can feel isolating, especially when first diagnosed — but there are people who know what you’re going through and there are resources to help you get the support you may need.

Meet Franchesca, living with MS since 2017.

Let Franchesca tell you about her journey — from the day she was diagnosed to how she turns her mood around with her MS is bothering her. See Franchesca’s stories and those from others on the Living with MS page.

Franchesca

Style Maven. Everybody’s BFF. Proving you can live out loud while living with MS.

Franchesca's stories

OCREVUS CONNECTS® is a free program dedicated to helping you become comfortable with your treatment.

Here are just a few of the ways OCREVUS CONNECTS® can support you:

  • One-on-one educational sessions to help you better understand MS and OCREVUS
  • Assistance finding treatment location options to discuss with you healthcare provider
  • Explaining what to expect during the infusion process and answering your questions

Support is also available for financial matters, including:

  • Help understanding your insurance and how it can cover your treatment
  • Identifying financial assistance options, including the OCREVUS Co-pay Program (if eligible)

The OCREVUS Co-pay Program: Eligibility criteria apply. Not valid for patients using federal or state government programs to pay for their medicine and/or administration of their Genentech medicine. Patients must be taking the Genentech medicine for an FDA-approved indication. Please visit the Co-pay Program website for the full list of Terms and Conditions.

Connect With Support
Learn About Financial Assistance

Important Safety Information & Indications

What are OCREVUS and OCREVUS ZUNOVO?

OCREVUS and OCREVUS ZUNOVO are prescription medicines used to treat:

  • Relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults
  • Primary progressive MS, in adults.

It is not known if OCREVUS and OCREVUS ZUNOVO are safe and effective in children.

Who should not receive OCREVUS or OCREVUS ZUNOVO?

Do not receive OCREVUS or OCREVUS ZUNOVO if you:

  • have an active hepatitis B virus (HBV) infection.
  • have had a life-threatening administration reaction to ocrelizumab.
  • have had a life-threatening allergic reaction to ocrelizumab, hyaluronidase, or any of the ingredients of OCREVUS ZUNOVO. Tell your healthcare provider if you have had an allergic reaction to OCREVUS or OCREVUS ZUNOVO or any of their ingredients in the past.

What is the most important information I should know about OCREVUS and OCREVUS ZUNOVO?

OCREVUS and OCREVUS ZUNOVO can cause serious side effects, including:

  • Infusion reactions (OCREVUS): Infusion reactions are a common side effect of OCREVUS, which can be serious and may require you to be hospitalized. You will be monitored during your infusion and for at least 1 hour after each infusion of OCREVUS for signs and symptoms of an infusion reaction.
  • Injection reactions (OCREVUS ZUNOVO): Injection reactions are a common side effect of OCREVUS ZUNOVO, which can be serious and may require you to be hospitalized. You will be monitored for signs and symptoms of an injection reaction when you receive OCREVUS ZUNOVO. This will happen during all injections for at least 1 hour after your first injection, and for at least 15 minutes after all injections following the first injection.

Tell your healthcare provider or nurse if you get any of these symptoms:

  • itchy skin
  • trouble breathing
  • nausea
  • shortness of breath
  • rash
  • throat irritation or pain
  • headache
  • fatigue
  • hives
  • feeling faint
  • swelling of the throat
  • fast heartbeat
  • tiredness
  • fever
  • dizziness
  • coughing or wheezing
  • redness on your face (flushing)

Additionally, for OCREVUS ZUNOVO:

  • injection site pain
  • swelling
  • redness

These infusion and injection reactions can happen during or up to 24 hours after administration. It is important that you call your healthcare provider right away if you get any of the signs or symptoms listed above after each infusion or injection.

  • Infection:
    • Infections are a common side effect. OCREVUS and OCREVUS ZUNOVO increase your risk of getting upper respiratory tract infections, lower respiratory tract infections, skin infections, and herpes infections. Serious infections can happen with OCREVUS and OCREVUS ZUNOVO, which can be life-threatening or cause death. Tell your healthcare provider if you have an infection or have any of the following signs of infection including fever, chills, or a cough that does not go away, or painful urination. Signs of herpes infection include: cold sores, shingles, genital sores, skin rash, pain, and itching. Signs of more serious herpes infection include: changes in vision, eye redness or eye pain, severe or persistent headache, stiff neck, and confusion. Signs of infection can happen during treatment or after you have received your last dose of OCREVUS or OCREVUS ZUNOVO. Tell your healthcare provider right away if you have an infection. Your healthcare provider should delay your treatment with OCREVUS or OCREVUS ZUNOVO until your infection is gone.
      • Hepatitis B virus (HBV) reactivation: Before starting treatment with ocrelizumab, your healthcare provider will do blood tests to check for hepatitis B viral infection. If you have ever had hepatitis B virus infection, the hepatitis B virus may become active again during or after treatment with OCREVUS or OCREVUS ZUNOVO. Hepatitis B virus becoming active again (called reactivation) may cause serious liver problems including liver failure or death. Your healthcare provider will monitor you if you are at risk for hepatitis B virus reactivation during treatment and after you stop receiving OCREVUS or OCREVUS ZUNOVO.
      • Weakened immune system: OCREVUS or OCREVUS ZUNOVO taken before or after other medicines that weaken the immune system could increase your risk of getting infections.
  • Progressive Multifocal Leukoencephalopathy (PML): PML is a rare brain infection that usually leads to death or severe disability and has been reported with ocrelizumab. Symptoms of PML get worse over days to weeks. It is important that you call your healthcare provider right away if you have any new or worsening neurologic signs or symptoms that have lasted several days, including problems with:
    • thinking
    • eyesight
    • strength
    • balance
    • weakness on 1 side of your body
    • using your arms or legs
  • Decreased immunoglobulins: OCREVUS and OCREVUS ZUNOVO may cause a decrease in some types of immunoglobulins. Your healthcare provider will do blood tests to check your blood immunoglobulin levels.

Before receiving OCREVUS or OCREVUS ZUNOVO, tell your healthcare provider about all of your medical conditions, including if you:

  • have or think you have an infection. See “What is the most important information I should know about OCREVUS and OCREVUS ZUNOVO?”
  • have ever taken, take, or plan to take medicines that affect your immune system, or other treatments for MS. These medicines could increase your risk of getting an infection.
  • have ever had hepatitis B or are a carrier of the hepatitis B virus.
  • have a history of inflammatory bowel disease or colitis.
  • have had a recent vaccination or are scheduled to receive any vaccinations.
    • You should receive any required ‘live’ or ‘live-attenuated’ vaccines at least 4 weeks before you start treatment with OCREVUS or OCREVUS ZUNOVO. You should not receive ‘live’ or ‘live-attenuated’ vaccines while you are being treated with OCREVUS or OCREVUS ZUNOVO and until your healthcare provider tells you that your immune system is no longer weakened.
    • When possible, you should receive any ‘non-live’ vaccines at least 2 weeks before you start treatment with OCREVUS or OCREVUS ZUNOVO. If you would like to receive any non-live (inactivated) vaccines, including the seasonal flu vaccine, while you are being treated with OCREVUS or OCREVUS ZUNOVO, talk to your healthcare provider.
    • If you have a baby and you received OCREVUS or OCREVUS ZUNOVO during your pregnancy, it is important to tell your baby’s healthcare provider about receiving OCREVUS or OCREVUS ZUNOVO so they can decide when your baby should be vaccinated.
  • are pregnant, think that you might be pregnant, or plan to become pregnant. It is not known if OCREVUS and OCREVUS ZUNOVO will harm your unborn baby. You should use birth control (contraception) during treatment with OCREVUS and OCREVUS ZUNOVO and for 6 months after your last dose of OCREVUS or OCREVUS ZUNOVO. Talk with your healthcare provider about what birth control method is right for you during this time. Tell your healthcare provider if you become pregnant while receiving OCREVUS or OCREVUS ZUNOVO.
  • are breastfeeding or plan to breastfeed. It is not known if OCREVUS and OCREVUS ZUNOVO pass into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you take OCREVUS or OCREVUS ZUNOVO.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of OCREVUS and OCREVUS ZUNOVO?

OCREVUS and OCREVUS ZUNOVO may cause serious side effects, including:

  • Risk of cancers (malignancies) including breast cancer: Follow your healthcare provider’s instructions about standard screening guidelines for breast cancer.
  • Inflammation of the colon, or colitis: Tell your healthcare provider if you have any symptoms of colitis, such as:
    • Diarrhea (loose stools) or more frequent bowel movements than usual
    • Stools that are black, tarry, sticky or have blood or mucus
    • Severe stomach-area (abdomen) pain or tenderness

The most common side effects of OCREVUS ZUNOVO include:

  • Injection reactions
  • Respiratory tract infections
  • Skin infections

These are not all the possible side effects of OCREVUS and OCREVUS ZUNOVO.

For more information, go to www.OCREVUS.com or call 1-844-627-3887.

Please see additional Important Safety Information throughout and click here for full Prescribing Information and Medication Guide for OCREVUS.

Please see additional Important Safety Information throughout and click here for full Prescribing Information and Medication Guide for OCREVUS ZUNOVO.

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